AG 555

Research use only, not for human use.

AG 555 is an EGFR tyrosine kinase inhibitor.

AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor.

AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle.Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells.Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence. Cell Proliferation Assay Cell Line:NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells.Concentration:100 μM.Incubation Time:1 hour.Result:Inhibited Mo-MuLV proviral DNA integration.

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AG555 | AG 555 | AG-555

Others

BMI-1

EGFR

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133550-34-2

322.36

C19H18N2O3

>98% (HPLC)

DMSO : ≥ 100 mg/mL. 310.21 mM

c1ccc(cc1)CCCNC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide

(-20℃)

With Ice Pack

≥ 2 years